Central OC Times

UC Irvine has been awarded a $1.19 million grant from the Tobacco-Related Disease Research Program to lead a study on how DNA genetic variations might influence nicotine addiction. The research aims to provide deeper insights into neurological processes related to nicotine addiction, potentially leading to more effective prevention and treatment strategies for smoking and vaping habits.

Principal investigator Shahrdad Lotfipour, assistant professor of emergency medicine at UC Irvine, expressed the team's approach towards the study, stating, "Using cutting-edge techniques in chemistry and biology, our focus is to identify a particular genetic variation known as a single nucleotide polymorphism within a gene associated with nicotine addiction."

The study will specifically investigate the impact of genetic variations on how nicotine affects brain function and behavior across different age groups, focusing on neurons associated with the pleasure and reward system in the midbrain. Lotfipour emphasized the potential implications of the research, highlighting its significance in combating substance abuse and addressing the increase in teenage vaping and drug use. He stated, "Our findings may serve as the cornerstone for arming healthcare professionals with new and powerful tools to combat the challenges of addiction."

The research team includes experts from UC Irvine's School of Pharmacy & Pharmaceutical Sciences, such as Frances Leslie, Thomas Martinez, and graduate student Emily Castro, alongside members from the Lotfipour laboratory group.

The Tobacco-Related Disease Research Program, funded through the state's tobacco tax and individual contributions, collaborates with the California Department of Public Health and Department of Education to explore ways to reduce tobacco use and related diseases.

UC Irvine's involvement in this study aligns with its commitment to excellence in research and academic achievement. The university's Brilliant Future campaign, launched in 2019, aims to raise awareness and support for various initiatives, including student success, health, and research.

For more information about UC Irvine and its research initiatives, visit www.uci.edu.