Central OC Times

Research from the University of California, Irvine has shown that disruption of the circadian clock may accelerate colorectal cancer progression by affecting the gut microbiome and intestinal barrier function. This discovery could lead to new prevention and treatment strategies.

The study, published in Science Advances, provides insights into how changes occur in the gut microbiome when the circadian clock is disturbed in colorectal cancer cases. "There is an alarming rise in early-onset colorectal cancer in adults under the age of 50," said Selma Masri, associate professor of biological chemistry. "Circadian misalignment through extended light exposure, late-night meals and other environmental factors could be driving these cases."

Using mouse models, researchers found that disrupting the circadian clock alters gut bacteria diversity and abundance, which is exacerbated by cancer development. They identified changes in microbial pathways involved in nucleic acids, amino acids, and carbohydrate metabolism. These changes were linked to reduced levels of intestinal mucus, increasing permeability of the intestinal lining and potentially accelerating cancer progression.

"While these findings are important, more work needs to be done," Masri added. "Long-term studies will be critical in determining whether circadian misalignment drives cancer and how we might prevent it."

The study was led by Rachel Fellows with contributions from Marcus M. Seldin, Nicholas R. Pannunzio, Sung Kook Chun, Alisa L. Mahieu, Bridget Fortin, Wei A. Song, and Natalie Larson from UC Irvine's School of Medicine’s Department of Biological Chemistry.

This research was supported by grants from the National Institutes of Health, the Concern Foundation and Johnson & Johnson.

UC Irvine launched its Brilliant Future campaign on Oct. 4, 2019 to raise awareness and support for various initiatives including student success and health research.

Founded in 1965, UC Irvine is a member of the Association of American Universities and ranks among the nation’s top public universities according to U.S. News & World Report.

For more information about UC Irvine or media access details visit www.uci.edu or news.uci.edu.