By Central OC Times |
Aug 6, 2024
Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, known as beta-amyloid plaques, associated with late-onset Alzheimer’s disease. Utilizing single-cell Merfish spatial transcriptomics technology, the team profiled the effects of the mutation across multiple cortical and subcortical brain regions, providing unprecedented insights at the single-cell level.